Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylation

BACKGROUND: Methylation-mediated silencing of genes is one epigenetic mechanism implicated in cancer. Studies regarding the role of modulation of gene expression utilizing inhibitors of DNA methylation, such as decitabine, in osteosarcoma (OS) have been limited. A biological understanding of the ove...

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Main Authors: Al-Romaih, Khaldoun, Somers, Gino R, Bayani, Jane, Hughes, Simon, Prasad, Mona, Cutz, Jean-Claude, Xue, Hui, Zielenska, Maria, Wang, Yuzhuo, Squire, Jeremy A
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2007
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034371/
https://ncbi.nlm.nih.gov/pubmed/17845729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-7-14
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