Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylation

BACKGROUND: Methylation-mediated silencing of genes is one epigenetic mechanism implicated in cancer. Studies regarding the role of modulation of gene expression utilizing inhibitors of DNA methylation, such as decitabine, in osteosarcoma (OS) have been limited. A biological understanding of the ove...

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Detalhes bibliográficos
Main Authors: Al-Romaih, Khaldoun, Somers, Gino R, Bayani, Jane, Hughes, Simon, Prasad, Mona, Cutz, Jean-Claude, Xue, Hui, Zielenska, Maria, Wang, Yuzhuo, Squire, Jeremy A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034371/
https://ncbi.nlm.nih.gov/pubmed/17845729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-7-14
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