Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylation

BACKGROUND: Methylation-mediated silencing of genes is one epigenetic mechanism implicated in cancer. Studies regarding the role of modulation of gene expression utilizing inhibitors of DNA methylation, such as decitabine, in osteosarcoma (OS) have been limited. A biological understanding of the ove...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Al-Romaih, Khaldoun, Somers, Gino R, Bayani, Jane, Hughes, Simon, Prasad, Mona, Cutz, Jean-Claude, Xue, Hui, Zielenska, Maria, Wang, Yuzhuo, Squire, Jeremy A
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2007
Ämnen:
Primary Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034371/
https://ncbi.nlm.nih.gov/pubmed/17845729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-7-14
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk