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Trans cooperativity by a split DNA recombinase: the central and catalytic domains of bacteriophage lambda integrase cooperate in cleaving DNA substrates when the two domains are not covalently linked
Site-specific recombinases of the λ-integrase family recognize and cleave their cognate DNA sites through cooperative binding to opposite sides of the DNA substrate by a C-terminal catalytic domain and a flexibly linked ‘core-binding’ domain; regulation of this cleavage is achieved via the formation...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2034338/ https://ncbi.nlm.nih.gov/pubmed/17531268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.04.024 |
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