Bryostatin 1, a novel antineoplastic agent and protein kinase C activator, induces human myalgia and muscle metabolic defects: a 31P magnetic resonance spectroscopic study.

Bryostatin 1, a novel antineoplastic agent and protein kinase C (PKC) activator, has been found to induce myalgia (muscle pain) 48 h after administration in clinical trials. This is the dose-limiting toxicity and has restricted the duration of therapy in phase I trials. To investigate the mechanisms...

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Main Authors: Hickman, P. F., Kemp, G. J., Thompson, C. H., Salisbury, A. J., Wade, K., Harris, A. L., Radda, G. K.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1995
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034030/
https://ncbi.nlm.nih.gov/pubmed/7547256
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