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Folding of the conserved domain but not of flanking regions in the integrin β(2) subunit requires association with the α subunit

We have used immunoprecipitation with mAbs to probe folding during biosynthesis of the β(2) integrin subunit of lymphocyte function-associated antigen 1 (LFA-1; CD11a/CD18) before and after association with the α(L) subunit. An evolutionarily conserved region is present in the β(2) subunit between a...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Huang, Chichi, Lu, Chafen, Springer, Timothy A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20338/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9096362/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.7.3156
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