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JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression
A role for the transcription factor JunB in proliferation control was investigated in genetically modified mouse fibroblasts. Increased JunB expression induced high levels of the cyclin-dependent kinase inhibitor p16(INK4a), leading to premature senescence in primary cells and reduced proliferation...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2000
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC203376/ https://ncbi.nlm.nih.gov/pubmed/10856241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.12.2969 |
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