Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase.

We report DNA interstrand cross-linking caused by the anti-tumour indoloquinone EO9 following reductive activation with purified rat liver DT-diaphorase or xanthine oxidase. Reduction was a necessary event for cross-linking to occur. DNA cross-link formation by EO9 following DT-diaphorase reduction...

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Autors principals: Maliepaard, M., Wolfs, A., Groot, S. E., de Mol, N. J., Janssen, L. H.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1995
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033736/
https://ncbi.nlm.nih.gov/pubmed/7536024
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