Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes.

Human liver carcinoma cells (BEL-7404) and human KB adenocarcinoma cells were selected by stepwise increases in cisplatin. Drug sensitivity assays indicated that the IC50 value for 7404-CP7.5 cells was 49 micrograms ml-1 cisplatin, 111-fold higher than for the parental hepatoma cells. The IC50 value...

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Autori principali: Shen, D. W., Akiyama, S., Schoenlein, P., Pastan, I., Gottesman, M. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1995
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033730/
https://ncbi.nlm.nih.gov/pubmed/7710928
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