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DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.

Aerobic sensitivity to indoloquinone EO9 has been shown to correlate with cellular levels of the two-electron reducing enzyme DT-diaphorase. However, little is known about the relative roles of one- and two-electron reducing enzymes in the hypoxic cytotoxicity of EO9. We have characterised a panel o...

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Autori principali: Plumb, J. A., Gerritsen, M., Workman, P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1994
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033714/
https://ncbi.nlm.nih.gov/pubmed/7526885
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