The potential for enhanced tumour localisation by poly(ethylene glycol) modification of anti-CEA antibody.

Attachment of poly(ethylene glycol) (PEG) to proteins can greatly alter their pharmacological properties, including extending the plasma half-life and reducing immunogenicity, both of which are potentially beneficial to tumour targeting. IgG, F(ab')2 and Fab' fragments of the anti-CEA anti...

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Main Authors: Pedley, R. B., Boden, J. A., Boden, R., Begent, R. H., Turner, A., Haines, A. M., King, D. J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033704/
https://ncbi.nlm.nih.gov/pubmed/7981064
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