Mutation of the p53 gene precedes aneuploid clonal divergence in colorectal carcinoma.

To establish whether p53 mutation precedes or follows clonal divergence in human colorectal carcinomas, 17 tumours were analysed at multiple sites (2-5 each) for single-strand conformation polymorphisms (SSCP) within exons 5-8 of the p53 gene. A previous study had demonstrated subclones of differing...

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Hauptverfasser: Carder, P. J., Cripps, K. J., Morris, R., Collins, S., White, S., Bird, C. C., Wyllie, A. H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1995
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033599/
https://ncbi.nlm.nih.gov/pubmed/7841032
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