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Loss of heterozygosity on chromosome 22 in ovarian carcinoma is distal to and is not accompanied by mutations in NF2 at 22q12.

Frequent loss of heterozygosity (LOH) has been reported on 22q in ovarian carcinoma, implying the presence of a tumour-suppressor gene. The neurofibromatosis type 2 gene (NF2) at 22q12 is a plausible candidate. Analysis of 9 of the 17 exons of NF2 by single-strand conformational polymorphism (SSCP)...

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Bibliografske podrobnosti
Main Authors: Englefield, P., Foulkes, W. D., Campbell, I. G.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1994
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033554/
https://ncbi.nlm.nih.gov/pubmed/7947096
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