Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines.

Multidrug-resistant (MDR) cell lines often have a compound phenotype, combining reduced drug accumulation with a decrease in topoisomerase II. We have analysed alterations in topoisomerase II in MDR derivatives of the human lung cancer cell line SW-1573. Selection with doxorubicin frequently resulte...

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Main Authors: Eijdems, E. W., de Haas, M., Timmerman, A. J., Van der Schans, G. P., Kamst, E., de Nooij, J., Astaldi Ricotti, G. C., Borst, P., Baas, F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033439/
https://ncbi.nlm.nih.gov/pubmed/7819046
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