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Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour-selective therapy.

The viability of cells within the acidic microenvironment found in solid tumours is expected to depend on the regulation of intracellular pH (pHi). 5-(N,N-hexamethylene) amiloride (HMA) is a potent inhibitor of the Na+/H+ antiport, a major mechanism for the regulation of pHi. We have therefore studi...

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Bibliografiske detaljer
Main Authors: Luo, J., Tannock, I. F.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1994
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033413/
https://ncbi.nlm.nih.gov/pubmed/7917906
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