Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours.

Cell killing can be achieved in an acidic environment in tissue culture (medium pH less than 7.0) by agents (nigericin, carbonylcyanide-3-chlorophenylhydrazone (CCCP)) which transport protons from the extracellular space into the cytoplasm. Cell killing is enhanced when these agents are used in comb...

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Bibliographic Details
Main Authors: Newell, K., Wood, P., Stratford, I., Tannock, I.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1977830/
https://ncbi.nlm.nih.gov/pubmed/1503904
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