Lack of effect of interferon alpha 2a upon fluorouracil pharmacokinetics.

The disposition of 5-fluorouracil (FUra) was studied in 19 colorectal cancer patients during treatment with FUra and high-dose leucovorin (LV) with or without interferon alpha 2a (IFN-alpha). All received LV 200 mg m-2 over 2 h, then FUra 400 mg m-2 over 5 min then FUra 400 mg m-2 over 22 h, repeate...

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Autors principals: Seymour, M. T., Patel, N., Johnston, A., Joel, S. P., Slevin, M. L.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033410/
https://ncbi.nlm.nih.gov/pubmed/7917928
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