Oxygen dependence of the cytotoxicity and metabolic activation of 4-alkylamino-5-nitroquinoline bioreductive drugs.

The cytotoxic potency of 4-alkylamino-5-nitroquinoline drugs in AA8 cell cultures is enhanced up to 60-fold under hypoxia, with wide variations in selectivity for hypoxic cells observed for different members of this series. This study uses three representative 5-nitroquinolines to examine whether th...

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Bibliografske podrobnosti
Main Authors: Siim, B. G., Atwell, G. J., Wilson, W. R.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1994
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033401/
https://ncbi.nlm.nih.gov/pubmed/7917903
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