The structural integrity exerted by N-terminal pyroglutamate is crucial for the cytotoxicity of frog ribonuclease from Rana pipiens

Onconase, a cytotoxic ribonuclease from Rana pipiens, possesses pyroglutamate (Pyr) at the N-terminus and has a substrate preference for uridine–guanine (UG). To identify residues responsible for onconase’s cytotoxicity, we cloned the rpr gene from genomic DNA and expressed it in Escherichia coli BL...

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Autori principali: Liao, You-Di, Wang, Sui-Chi, Leu, Ying-Jen, Wang, Chiu-Feng, Chang, Shu-Ting, Hong, Yu-Ting, Pan, Yun-Ru, Chen, Chinpan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC203329/
https://ncbi.nlm.nih.gov/pubmed/12954760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg746
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