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Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair

The repair enzymes thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) remove thymines from T:G mismatches resulting from deamination of 5-methylcytosine. Thymine glycol, a common DNA lesion produced by oxidative stress, can arise from oxidation of thymine or from oxidative deamina...

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Udgivet i:Nucleic Acids Res
Principais autores: Yoon, Jung-Hoon, Iwai, Shigenori, O’Connor, Timothy R., Pfeifer, Gerd P.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC203315/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12954776/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg730
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