Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair

The repair enzymes thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) remove thymines from T:G mismatches resulting from deamination of 5-methylcytosine. Thymine glycol, a common DNA lesion produced by oxidative stress, can arise from oxidation of thymine or from oxidative deamina...

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Hlavní autoři: Yoon, Jung-Hoon, Iwai, Shigenori, O’Connor, Timothy R., Pfeifer, Gerd P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2003
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC203315/
https://ncbi.nlm.nih.gov/pubmed/12954776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg730
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