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Protein Kinase C γ Mutations in the C1B Domain Cause Caspase-3-linked apoptosis in Lens Epithelial Cells through Gap Junctions
Failure to control oxidative stress is closely related to aging and to a diverse range of human diseases. We have reported that protein kinase C γ (PKCγ) acts as a primary oxidative stress sensor in the lens. PKCγ has a Zn-finger C1B stress switch domain, residues 101-150. Mutation, H101Y, in the C1...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2030616/ https://ncbi.nlm.nih.gov/pubmed/17493614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2007.03.007 |
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