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Encoded combinatorial chemistry: Synthesis and screening of a library of highly functionalized pyrrolidines

The application of a new encoding technology for drug discovery is described. A combinatorial library of mercaptoacyl pyrrolidines has been prepared on a beaded polymeric support. Each polymer bead carries one library constituent in association with an oligomeric “tag,” the structure of which is a r...

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Autores principales: Maclean, Derek, Schullek, John R., Murphy, Martin M., Ni, Zhi-Jie, Gordon, Eric M., Gallop, Mark A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences of the USA 1997
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC20277/
https://ncbi.nlm.nih.gov/pubmed/9096301
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