Encoded combinatorial chemistry: Synthesis and screening of a library of highly functionalized pyrrolidines

The application of a new encoding technology for drug discovery is described. A combinatorial library of mercaptoacyl pyrrolidines has been prepared on a beaded polymeric support. Each polymer bead carries one library constituent in association with an oligomeric “tag,” the structure of which is a r...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Maclean, Derek, Schullek, John R., Murphy, Martin M., Ni, Zhi-Jie, Gordon, Eric M., Gallop, Mark A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Physical Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20277/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9096301/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.7.2805
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