Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2

To clarify RAD51 interactions controlling homologous recombination, we report here the crystal structure of the full-length RAD51 homolog from Pyrococcus furiosus. The structure reveals how RAD51 proteins assemble into inactive heptameric rings and active DNA-bound filaments matching three-dimension...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shin, David S., Pellegrini, Luca, Daniels, Douglas S., Yelent, Biana, Craig, Lisa, Bates, Debbie, Yu, David S., Shivji, Mahmud K., Hitomi, Chiharu, Arvai, Andrew S., Volkmann, Niels, Tsuruta, Hiro, Blundell, Tom L., Venkitaraman, Ashok R., Tainer, John A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2003
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC202371/
https://ncbi.nlm.nih.gov/pubmed/12941707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg429
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