BRCA2 stabilises RAD51 and DMC1 nucleoprotein filaments through a conserved interaction mode
Abstract BRCA2 is essential for DNA repair by homologous recombination in mitosis and meiosis. It interacts with recombinases RAD51 and DMC1 to facilitate the formation of nucleoprotein filaments on resected DNA ends that catalyse recombination-mediated repair. BRCA2’s BRC repeats bind and disrupt R...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2024-09-01
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| Colecção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-024-52699-3 |
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