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Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals

Apurinic/apyrimidinic (AP) endonuclease (APE; EC 4.2.99.18) plays a central role in repair of DNA damage due to reactive oxygen species (ROS) because its DNA 3′-phosphoesterase activity removes 3′ blocking groups in DNA that are generated by DNA glycosylase/AP-lyases during removal of oxidized bases...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Ramana, Chilakamarti V., Boldogh, Istvan, Izumi, Tadahide, Mitra, Sankar
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20213/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9560228/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.9.5061
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