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Loss of cochlear [Formula: see text] secretion causes deafness via endolymphatic acidification and inhibition of Ca(2+) reabsorption in a Pendred syndrome mouse model

Pendred syndrome, characterized by childhood deafness and postpuberty goiter, is caused by mutations of SLC26A4, which codes for the anion exchanger pendrin. The goal of the present study was to determine how loss of pendrin leads to hair cell degeneration and deafness. We evaluated pendrin function...

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Autors principals: Wangemann, Philine, Nakaya, Kazuhiro, Wu, Tao, Maganti, Rajanikanth J., Itza, Erin M., Sanneman, Joel D., Harbidge, Donald G., Billings, Sara, Marcus, Daniel C.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2020516/
https://ncbi.nlm.nih.gov/pubmed/17299139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00487.2006
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