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Epithelial Cell Stretching and Luminal Acidification Lead to a Retarded Development of Stria Vascularis and Deafness in Mice Lacking Pendrin
Loss-of-function mutations of SLC26A4/pendrin are among the most prevalent causes of deafness. Deafness and vestibular dysfunction in the corresponding mouse model, Slc26a4(−/−), are associated with an enlargement and acidification of the membranous labyrinth. Here we relate the onset of expression...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056798/ https://ncbi.nlm.nih.gov/pubmed/21423764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017949 |
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