Drug-Induced Epigenetic Changes Produce Drug Tolerance

Tolerance to drugs that affect neural activity is mediated, in part, by adaptive mechanisms that attempt to restore normal neural excitability. Changes in the expression of ion channel genes are thought to play an important role in these neural adaptations. The slo gene encodes the pore-forming subu...

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Bibliographic Details
Main Authors: Wang, Yan, Krishnan, Harish R, Ghezzi, Alfredo, Yin, Jerry C. P, Atkinson, Nigel S
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2020501/
https://ncbi.nlm.nih.gov/pubmed/17941717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050265
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