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Stable alteration of pre-mRNA splicing patterns by modified U7 small nuclear RNAs

In several forms of β-thalassemia, mutations in the second intron of the β-globin gene create aberrant 5′ splice sites and activate a common cryptic 3′ splice site upstream. As a result, the thalassemic β-globin pre-mRNAs are spliced almost exclusively via the aberrant splice sites leading to a defi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gorman, Linda, Suter, Daniel, Emerick, Victoria, Schümperli, Daniel, Kole, Ryszard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The National Academy of Sciences 1998
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC20190/
https://ncbi.nlm.nih.gov/pubmed/9560205
Tagiau: Ychwanegu Tag
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