Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: a comparison of tricyclo-DNA with LNA

The nuclear antisense properties of a series of tricyclo (tc)-DNA oligonucleotide 9–15mers, targeted against the 3′ and 5′ splice sites of exon 4 of cyclophilin A (CyPA) pre-mRNA, were evaluated in HeLa cells and compared with those of corresponding LNA-oligonucleotides. While the 9mers showed no si...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Ittig, Damian, Liu, Songkai, Renneberg, Dorte, Schümperli, Daniel, Leumann, Christian J.
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 2004
Sujets:	Articles
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC373297/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14726483/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh187
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