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Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins

The ability of iron to catalyze formation of reactive oxygen species significantly contributes to its toxicity in cells and animals. Iron uptake and distribution is regulated tightly in mammalian cells, in part by iron regulatory protein 2 (IRP2), a protein that is degraded efficiently by the protea...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Iwai, Kazuhiro, Drake, Steven K., Wehr, Nancy B., Weissman, Allan M., LaVaute, Timothy, Minato, Nagahiro, Klausner, Richard D., Levine, Rodney L., Rouault, Tracey A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1998
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20189/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9560204/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.9.4924
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