Anti–β(2)-microglobulin monoclonal antibodies induce apoptosis in myeloma cells by recruiting MHC class I to and excluding growth and survival cytokine receptors from lipid rafts

We recently showed that monoclonal antibodies (mAbs) against β(2)-microglobulin (β(2)M) have a remarkably strong apoptotic effect on myeloma cells. The mAbs induced apoptosis by recruiting major histocompatibility complex (MHC) class I to lipid rafts, activated c-Jun N-terminal kinase (JNK), and inh...

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Detalhes bibliográficos
Main Authors: Yang, Jing, Zhang, Xiang, Wang, Ji, Qian, Jianfei, Zhang, Liang, Wang, Michael, Kwak, Larry W., Yi, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2018676/
https://ncbi.nlm.nih.gov/pubmed/17644731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-094417
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