In vivo (13)C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling

The cerebral tricarboxylic acid (TCA) cycle rate and the rate of glutamine synthesis were measured in rats in vivo under normal physiological and hyperammonemic conditions using (13)C NMR spectroscopy. In the hyperammonemic animals, blood ammonia levels were raised from control values of ≈0.05 mM to...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Sibson, N. R., Dhankhar, A., Mason, G. F., Behar, K. L., Rothman, D. L., Shulman, R. G.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20152/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122259/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2699
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