Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation

AIMS: 1) To characterize the variability of multiple-dose halofantrine pharmacokinetics over time in healthy adults, 2) to correlate the pharmacodynamic measure electrocardiographic (ECG) QT interval with (+)- and (−)-halofantrine plasma concentration and 3) to evaluate the safety and tolerance of h...

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Detalhes bibliográficos
Main Authors: Abernethy, Darrell R, Wesche, David L, Barbey, Jean T, Ohrt, Colin, Mohanty, Sarina, Pezzullo, John C, Schuster, Brian G
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2001
Assuntos:
Pharmacokinetics/Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2015022/
https://ncbi.nlm.nih.gov/pubmed/11298069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.00351.x
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