The intracellular activation of lamivudine (3TC) and determination of 2′-deoxycytidine-5′-triphosphate (dCTP) pools in the presence and absence of various drugs in HepG2 cells

AIMS: Lamivudine (3TC, 2′-deoxy-3′-thiacytidine) requires intracellular metabolism to its active 5′-triphosphate, 3TC-5′-triphosphate (3TCTP), to inhibit the replication of hepatitis B virus (HBV). We have investigated the activation of 3TC, in the presence and absence of a range of compounds, in He...

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Detalhes bibliográficos
Main Authors: Kewn, Stephen, Hoggard, Patrick G, Sales, Sean D, Johnson, Mark A, Back, David J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2015020/
https://ncbi.nlm.nih.gov/pubmed/11136299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00302.x
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