Effect of P-glycoprotein modulation on the clinical pharmacokinetics and adverse effects of morphine

AIMS: To investigate the effect of acute P-glycoprotein inhibition by the multidrug-resistance (MDR) modulator valspodar (SDZ PSC 833; PSC) on the pharmacokinetics, and potentially adverse pharmacodynamic effects of morphine, and its principal pharmacologically active metabolites, morphine-3-glucuro...

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Detalhes bibliográficos
Main Authors: Drewe, Jürgen, Ball, Howard A, Beglinger, Christoph, Peng, Bin, Kemmler, Andreas, Schächinger, Hartmut, Haefeli, Walter E
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Pharmacokinetics/Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014981/
https://ncbi.nlm.nih.gov/pubmed/10971308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00226.x
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