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CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system

AIMS: Terodiline has concentration dependent QT prolonging effects and thus the potential for cardiotoxicity. Pharmacogenetic variation in terodiline metabolism could be responsible for cardiotoxicity. We sought to determine whether CYP2D6 (debrisoquine hydroxylase) or CYP2C19 (S-mephenytoin hydroxy...

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Detalhes bibliográficos
Main Authors: Ford, Gary A, Wood, Susan M, Daly, Ann K
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014965/
https://ncbi.nlm.nih.gov/pubmed/10886124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00230.x
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