Nonspecific binding of drugs to human liver microsomes

AIMS: To characterize the nonspecific binding to human liver microsomes of drugs with varying physicochemical characteristics, and to develop a model for the effect of nonspecific binding on the in vitro kinetics of drug metabolism enzymes. METHODS: The extent of nonspecific binding to human liver m...

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Bibliographic Details
Main Authors: McLure, James A, Miners, John O, Birkett, Donald J
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2000
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Main Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014956/
https://ncbi.nlm.nih.gov/pubmed/10792203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00193.x
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