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Inhibition of debrisoquine hydroxylation with quinidine in subjects with three or more functional CYP2D6 genes

AIMS: To study whether the CYP2D6 capacity in ultrarapid metabolizers of debrisoquine due to duplication/multiduplication of a functional CYP2D6 gene, can be ‘normalised’ by low doses of the CYP2D6 inhibitor quinidine and whether this is dose-dependent. METHODS: Five ultrarapid metabolizers of debri...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Dalén, P, Dahl, M-L, Andersson, K, Bertilsson, L
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Blackwell Science Inc 2000
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014903/
https://ncbi.nlm.nih.gov/pubmed/10671914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2000.00120.x
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