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A new benzoxazine compound blocks KATP channels in pancreatic β cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo
BACKGROUND AND PURPOSE: The 2-propyl-1,4 benzoxazine (AM10) shows a peculiar behaviour in skeletal muscle, inhibiting or opening the ATP-sensitive K(+) (KATP) channel in the absence and presence of ATP, respectively. We focused on tissue selectivity and mechanism of action of AM10 by testing its eff...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014689/ https://ncbi.nlm.nih.gov/pubmed/17057758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706895 |
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