Inhalation of activated protein C inhibits endotoxin-induced pulmonary inflammation in mice independent of neutrophil recruitment

BACKGROUND AND PURPOSE: Intravenous administration of recombinant human activated protein C (rhAPC) is known to reduce lipopolysaccharide (LPS)-induced pulmonary inflammation by attenuating neutrophil chemotaxis towards the alveolar compartment. Ideally, one would administer rhAPC in pulmonary infla...

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Detalhes bibliográficos
Main Authors: Slofstra, S H, Groot, A P, Maris, N A, Reitsma, P H, Cate, H ten, Spek, C A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014647/
https://ncbi.nlm.nih.gov/pubmed/17016502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706915
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