Diazoxide acts more as a PKC-ɛ activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury

BACKGROUND AND PURPOSE: Diazoxide, a well-known opener of the mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel, has been demonstrated to exert cardioprotective effect against ischemic injury through the mitoK(ATP) channel and protein kinase C (PKC). We aimed to clarify the role of PKC isof...

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Detalhes bibliográficos
Main Authors: Kim, M-Y, Kim, M J, Yoon, I S, Ahn, J H, Lee, S H, Baik, E J, Moon, C-H, Jung, Y-S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014640/
https://ncbi.nlm.nih.gov/pubmed/17043673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706922
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