Effect of itraconazole on the pharmacokinetics of prednisolone and methylprednisolone and cortisol secretion in healthy subjects

AIMS: Itraconazole is a potent inhibitor of CYP3A4 activity and is often used in combination with corticosteroids. Since the latter are partly metabolized by CYP3A4, we studied the interaction between itraconazole, prednisone and methylprednisolone in healthy male subjects. METHODS: The effects of 4...

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Détails bibliographiques
Auteurs principaux: Lebrun-Vignes, B, Archer, V Corbrion, Diquet, B, Levron, J C, Chosidow, O, Puech, A J, Warot, D
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2001
Sujets:
Drug Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014476/
https://ncbi.nlm.nih.gov/pubmed/11422002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2001.01372.x
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