Pharmacokinetics of sabeluzole and dextromethorphan oxidation capacity in patients with severe hepatic dysfunction and healthy volunteers

AIMS: The primary objective of this study was to determine how the pharmacokinetics of sabeluzole, an investigational drug with specific effects on memory and learning abilities, are affected by chronic liver disease. Since sabeluzole is metabolised by CYP2D6, a secondary objective was to study the...

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Autores principales: Pageaux, G P, Micallef, J, Nataf, M Barugola, Levron, J C, Lacarelle, B, Le Moing, J P, Bouhours, P, Blin, O
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2001
Materias:
Short Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014438/
https://ncbi.nlm.nih.gov/pubmed/11259989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2001.01337.x
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