Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity

AIMS: To investigate the pharmacokinetics and safety of tolterodine and tolterodine metabolites after single-and multiple-dose administration in the absence and presence of ketoconazole, an inhibitor of cytochrome P450 (CYP) 3A4, in healthy volunteers with deficient CYP2D6 activity, i.e. poor metabo...

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Bibliografiske detaljer
Main Authors: Brynne, N, Forslund, C, Hallén, B, Gustafsson, L L, Bertilsson, L
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 1999
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014365/
https://ncbi.nlm.nih.gov/pubmed/10583027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00053.x
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