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COMT inhibition with tolcapone does not affect carbidopa pharmacokinetics in parkinsonian patients in levodopa/carbidopa (Sinemet®)

AIMS: Tolcapone is a novel catechol-O-methyltransferase (COMT) inhibitor used as an adjunct to levodopa/carbidopa or levodopa/benserazide therapy to improve treatment of Parkinson’s disease. The aim of the current study was to investigate the potential effect of tolcapone on the pharmacokinetics of...

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Autors principals: Jorga, Karin M, Nicholl, David J
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014326/
https://ncbi.nlm.nih.gov/pubmed/10510160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00027.x
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