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Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms
AIMS: To compare the oxidative metabolism of (S)-mephenytoin and proguanil in vitro and to determine the involvement of various cytochrome P450 isoforms. METHODS: The kinetics of the formation of 4′-hydroxymephenytoin and cycloguanil in human liver microsomes from 10 liver samples were determined, a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014289/ https://ncbi.nlm.nih.gov/pubmed/10417492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00005.x |
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