The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver

BACKGROUND AND PURPOSE: The antiepileptic drug valproic acid, a histone deacetylase (HDAC) inhibitor, is currently being tested as an anticancer agent. However, HDAC inhibitors may interact with anticancer drugs through induction of P-glycoprotein (P-gp, MDR1) expression. In this study we assessed w...

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Dettagli Bibliografici
Autori principali: Eyal, S, Lamb, J G, Smith-Yockman, M, Yagen, B, Fibach, E, Altschuler, Y, White, H S, Bialer, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2006
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014277/
https://ncbi.nlm.nih.gov/pubmed/16894351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706830
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