Greater antiarrhythmic activity of acute 17β-estradiol in female than male anaesthetized rats: correlation with Ca(2+) channel blockade

BACKGROUND AND PURPOSE: Female sex hormones may protect pre-menopausal women from sudden cardiac death. We therefore investigated the effects of the main female sex hormone, 17β-estradiol, on ischaemia-induced cardiac arrhythmias and on the L-type Ca(2+) current (I(CaL)). EXPERIMENTAL APPROACH: In v...

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Bibliografiske detaljer
Main Authors: Philp, K L, Hussain, M, Byrne, N F, Diver, M J, Hart, G, Coker, S J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2006
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014275/
https://ncbi.nlm.nih.gov/pubmed/16940993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706850
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