Tramadol, but not its major metabolite (mono-O-demethyl tramadol) depresses compound action potentials in frog sciatic nerves

BACKGROUND AND PURPOSE: Although tramadol is known to exhibit a local anaesthetic effect, how tramadol exerts this effect is not understood fully. EXPERIMENTAL APPROACH: The effects of tramadol and its metabolite mono-O-demethyl-tramadol (M1) on compound action potentials (CAPs) were examined by app...

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Detalhes bibliográficos
Main Authors: Katsuki, R, Fujita, T, Koga, A, Liu, T, Nakatsuka, T, Nakashima, M, Kumamoto, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014268/
https://ncbi.nlm.nih.gov/pubmed/16921387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706868
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